ABSTRACT
Background: Glaucoma is the most common cause of blindness in the world. If not recognized and treated early enough, open-angle glaucoma can be a severe ocular illness that can lead to blindness. A gradual loss of ganglion cells leads to the optic nerve head cupping, which is the pathogenic process. Objective: The main aim of this study was to determine if selective laser trabeculoplasty (SLT) is superior to topical medication as the first-line treatment for open-angle glaucoma.Material & Methods:This prospective comparative study was conducted in 225 patients (450 eyes) at Deen Mohd. Eye Hospital & Research Center from July 2019 to July 2021.The patients were randomly divided into two groups; Selective laser trabeculoplasty (SLT group)and medical therapy group.Results:The study was conducted between 25 to 85 years of patients where the majority were between 46 to 65 years age group;58% patientswere male, and 42% were female. The mean intraocular pressure (IOP) was 18.2mm Hg for the SLT group and 17.6mm Hg for the medical therapy group. Overall, mean pressures and IOP lowering were not statistically different between the two treatment groups.Conclusions:In the last follow-up, 11% of the eyes had been stepped to additional SLT in the SLT arm, and 27% of the eyes in the medical arm required more medications to reach the target IOP range. The main risk factor is high intraocular pressure; however additional potential risk factors include optic nerve vascular insufficiency, neuronal degeneration, and hereditary factors. More research and prospective trials on intraocular pressure control and disease progression are needed to understand the long-term implications.
ABSTRACT
Background:Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluateurinary interleukin-18 in the early post-burn period to predict the AKIfor the various degrees of burn patients. Methods:This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzedby using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests. Results:In this study, mean age of the burn patients was 32.41�.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was0.937 (CI, 0.871-1.000).Conclusions:According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients